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• A Delivery Mechanism, Not Just a Cargo: The copper-chelate hypothesis proposes that GHK facilitates copper uptake into cells — the peptide-bound ion enters through pathways distinct from free ionic copper, which is why the complex is biologically active at concentrations where free copper would be poorly tolerated (PMID 29986520)

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CuHQ and CuCQ The copper-containing compound NCI-109268 was identified as a proteasome inhibitor from a screening library of the National Cancer Institute (USA), which contains 1990 compounds ( As a topical antifungal drug used clinically, clioquinol (5-chloro-7-iodo-8-hydroxyquinoline, CQ) is an analog of 8-hydroxyquinoline