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Unlike chronic neurodegenerative diseases such as PD, AD, HD or ALS, which involve slowly progressive and multifactorial neuronal loss, stroke represents an acute insult where the timing of intervention is critical

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Other ROS-generating pathways than mitochondria contributing to the pathogenesis of diabetes involve xanthine oxidase, endoplasmic reticulum stress, cytosolic ROS-producing enzyme NADPH oxidase (NOX), uncoupled Nitric oxide synthase (NOS), and myeloperoxidase (Iacobini et al