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These responses include: Expressions of vascular endothelial growth factor (VEGF) Endothelial nitric oxide synthase (eNOS) Nerve growth factor (NGF) Neuronal nitric oxide synthase (nNOS) α1 & α2-adrenergic receptors (α1AR, α2AR) Tissue regeneration, neovascularization, angiogenesis and improvement of blood supply with new helicine arterioles and improved microcirculation