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Metabolic signature in primary cardiomyopathy Hypertrophic cardiomyopathy HCM, a genetic disorder caused by mutations in various genes, poses diagnostic challenges due to variable gene expression within families and phenotypic overlap with conditions like amyloidosis and hypertensive heart disease, risking misdiagnosis (Table 1)

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In adipose tissue, Roberti, Fernández, and Fraga, writing in Molecular Metabolism in 2021, established that NNMT sits at the crossroads of cellular metabolism and epigenetic regulation: its activity directly affects the methyl economy that governs gene expression and energy metabolism in fat cells