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Concordance between tumours and their matched models ( n = 440 pairs) was quantified in terms of the cosine similarity between their respective signature profiles

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These findings suggest that NAC should be used at a dose ≥ 1200 mg/day to prevent exacerbations in patients with a chronic bronchitis phenotype of COPD and airway obstruction, while regular doses (600 mg/day) may be sufficient in the absence of airway obstruction [37]